[MEGAFRAME] 2010: MEGAFRAME was successfully completed (see also MEGAFRAME Final Report , MEGAFRAME D6.4 Laboratory fluorescence microscopy demonstrator ), but work using the MEGAFRAME32 (32x32) and MEGAFRAME128 (128x160) devices has continued, as you can also see from the Publications section.

MEGAFRAME32 is being distributed by Photon Force Ltd (contact: This e-mail address is being protected from spam bots, you need JavaScript enabled to view it ).

In parallel, the follow-up FP7 ICT SPADnet project ( ) has been launched, dedicated to the use of SPAD arrays in medical imaging, most notably Positron Emission Tomography (PET), building on the MEGAFRAME scientific and technological achievements.


[MEGAFRAME] April 2010: MEGAFRAME was selected as one of "12 outstanding Commission-funded FET projects" showcased at the European Parliament in Strasbourg within the Science beyond Fiction exhibition, 20-21 April 2010, organised to introduce Members of the European Parliament to Future and Emerging Technologies (FET). E. Charbon [and J. Arlt] attended and presented a 3 part poster (poster 1 - poster 2 - poster 3). 


[MEGAFRAME] Oct. 2009: MEGAFRAME reports on the performance of an array of 32x32 plano-convex 50μm pitch microlenses (see LEOS 2009), fabricated by co-polymer casting in a photoresist replica mold, which have been characterized by a specially developed Optical Test Bench. The measured detection sensitivity increase reaches up to a factor of 35. This concentration factor is, to the best of our knowledge, presently the highest reported to date for any array of SPADs.


[MEGAFRAME] Sept. 2009: S. Donati, UNIPV, has been invited to present a talk at the 17th International Conference on Advanced Laser Technologies (ALT09), 26 Sept - 1 Oct 2009, Antalya, Turkey, and selected the MEGAFRAME project as a topic.


[MEGAFRAME] June-Sept. 2009: MEGAFRAME reports on the design and characterisation of 32x32 TDC/TAC plus single photon avalanche diode (SPAD) pixel arrays implemented in a 130nm imaging process, to create a single chip TCSPC sensor (see the IISW, CICC and ESSDERC Publications). To the best of our knowledge, this work constitutes the largest single-chip array of fully integrated TDCs/TACs so far reported. Each TDC/TAC-SPAD ensemble measures only 50x50μm2. It is thus one of the smallest ever demonstrated with deep sub-nanosecond time resolution.


[European R&D] July 2009: The European Commission has explicitly included single-photon and smart pixel based time-correlated imaging R&D into the ICT Call 5 Photonics 2009 topics (see EC Photonics unit website). This is fully in line with MEGAFRAME’s pioneering results, which proved that single photon arrays can indeed be implemented in deep sub-micron CMOS for time-correlated as well as intensity applications.


[MEGAFRAME] July 2009: MEGAFRAME reports on the a new low noise single-photon avalanche diode (SPAD) fabricated in a 130 nm CMOS imaging process (SSE 2009). To the best of our knowledge, the DCR (Dark Count Rate) per unit area achieved in these devices is the lowest ever reported in deep sub-micron CMOS SPADs.


[MEGAFRAME] May 2009: MEGAFRAME reports on the real-time hardware (FPGA) implementation of a new integration based FLIM lifetime calculation algorithm, called IEM, suitable for SPAD arrays (see ISCAS 2009). This approach enables direct lifetime calculation in parallel for every pixel. To the best of our knowledge, this is the first system that can generate real-time video-rate fluorescence lifetime images.


[MEGAFRAME] April 2009: MEGAFRAME was selected as one of the exhibits of the FET09 Science beyond Fiction conference, 21-23 April 2009, Prague. E. Charbon and R. Henderson attended and presented a 3 part poster (poster 1 - poster 2 - poster 3).


[MEGAFRAME] Jan. 2009: Dr. Robert Henderson, UNIED, has been invited to present a talk at the Rank Prize mini-symposium on Single-Photon Detectors, 12-15 Jan 2009, Grasmere, Lake District, UK.


[MEGAFRAME] May 2008: MEGAFRAME reports on the direct integration for lifetime extraction method (IEM), a new, simple, and hardware-only fluorescence-lifetime-imaging microscopy (FLIM) proposed to implement on-chip lifetime extractions (JOSA A 2008).

"130nm CMOS SPAD", invited presentation at SPIE Optics East (Sept. 2007)

July/Aug. 2007: MEGAFRAME reports on the first implementation of a Single Photon Avalanche Diode (SPAD) in 130 nm complementary metal–oxide–semiconductor (CMOS) technology - see also the JSTQE paper in the "Publications" section.


FBK/ITC press release, Oct. 2006 (original Italian version, English version).


Home arrow Partner Profiles arrow University of Edinburgh (UNIED)
University of Edinburgh (UNIED) PDF Print
Institute of Micro and Nano Systems & Collaborative Optical Spectroscopy

UNIED logoThe Institute for Integrated Micro and Nano Systems (IMNS) brings together researchers from integrated circuit design, system-on-chip design, microfabrication, MEMS, micro-machining and neural computation. Research activities range from industrially-focussed process development and low-power system-on-chip design to long-term research into circuit design, system architectures, micro-stereolithography and novel structures on silicon, with strong links to the life sciences. The Collaborative Optical Spectroscopy, Micromanipulation and Imaging Centre (COSMIC) is a centre for interdisciplinary research funded by SHEFC, Scottish Enterprise, industrial sponsors and normal research grants. COSMIC incorporates advanced characterisation, visualisation and control of materials at the molecular level. Interest and involvement from industries that need to characterise and control the properties of complex materials, including biological systems, at the molecular and nanoscale level is actively encouraged and the centre participates in numerous industry-led partnerships.

UNIED-INMS was among the pioneers in the development of CMOS imaging, creating the start-up company VLSI Vision which was subsequently to become the core competence centre of STMICRO's Imaging Division. UNIED-INMS has been active in CMOS image sensor development within these organisations for many years before rejoining academia to undertake research in optical biosensing. In its previous role in STMICRO partner UNIED-INMS worked on the world’s first single-chip video camera and on the design of low-noise, highly-parallel readout architectures for mobile and digital still camera applications [C-15,C-16]. UNIED-COSMIC is a diverse end-user community of senior scientists with extensive research in the field of biophotonics [C-6,C-17]. UNIED-IMNS and COSMIC have a successful track record of collaboration in a number of projects.

Dr. Robert Henderson is a lecturer at the School of Engineering and Electronics in the IMNS. In 1996, he was appointed senior VLSI engineer at VLSI Vision Ltd, Edinburgh, UK where he worked on the world’s first single chip video camera and was project leader for numerous other CMOS image sensors. From 2000, as principal VLSI engineer in ST Microelectronics Imaging Division he developed very high volume, low noise image sensors for mobile phone applications. He has thus extensive design experience and an exceptionally good relationship with the industrial partner STMICRO which should greatly facilitate development of the MEGAFRAME imager. He joined Edinburgh University in 2005 to pursue his research interests in CMOS integrated circuit design, imaging and biosensors. He is the author of 30 papers and 12 patents. He was awarded the 1990 IEE J. J. Thomson Premium.

Dr. David Dryden is a Reader in the School of Chemistry. Prior to this appointment he held a Royal Society University Research Fellowship and a Wolfson Foundation Fellowship. DD is the author of over 50 publications in biochemistry and biophysics. He uses optical methods such as fluorescence and circular dichroism to study proteins and DNA and has focused on the biochemistry and spectroscopy of the EcoKI molecular machine. Currently, he is working on the fluorescence imaging of single protein and DNA molecules.

Dr. Anita Jones is a Senior Lecturer in Physical Chemistry. She has extensive experience in luminescence spectroscopy, laser-induced fluorescence and time-resolved fluorescence studies of polyatomic molecules in solution phase, the solid state and supersonic molecular beams. Her PhD was on time-resolved fluorescence of molecular crystals followed by a PDRA in Prof. David Phillips' group at the Royal Institution where she carried out high resolution spectroscopy and lifetime measurements on jet-cooled molecules.

Nick Read is a Professor in Fungal Cell Biology within the Institute of Cell Biology. He has been an author on over 80 publications. His research is primarily concerned with analysing the regulation of hyphal growth and morphogenesis, especially in relation to hyphal fusion, vesicle trafficking; and calcium signalling. Much of his research is focussed on analysing living cells using a wide range of advanced imaging and measurement techniques in combination with vital fluorescent dyes and recombinant probes. Considerable emphasis is placed on interdisciplinary research.

Dr. J. Crain is a Reader in Physics. His background is in condensed matter physics and disordered materials with an emphasis on biologically-inspired problems. He is currently Director of the COSMIC Research Center at the University of Edinburgh, Leader of the Scottish Universities Physics Alliance (SUPA) Biophotonics Initiative, Fellow of the Institute of Physics(IOP), regular Visiting Professor at the IBM T.J. Watson Research Center in New York, member of the steering committees of the IoP Liquids Group and the Scottish Bioinformatics Research Network. He has extensive experience and high visibility in leading large collaborative research programs at the physical/life science interface in both academic and industrial sectors involving experiment and simulation. He has authored over 100 publications and holds 5 patents.

< Prev   Next >
© 2016 MEGAFRAME - Million Frame Per Second, Time-Correlated Single Photon Camera [IST FP6 FET Open]
Joomla! is Free Software released under the GNU/GPL License.